Endometrial stromal sarcoma with clonal complex chromosome abnormalities -Report of a case and review of the literature

Only eleven endometrial stromal sarcomas (ESS) with clonal chromosomal abno rmalities have been reported in the literature. Of these, four have been re ported to harbor the t(7;1 7) translocation. We report here an additional E SS that exhibited clonal complex chromosome abnormalities not described ear lier: 38,XX,- 1,del(1)(q11), -2,add(2)(p13),-3,der(4)add(4)(p12)psu dic(4;1 4)(q35;q11.2), add(6)(p21.3), add(7)(q22), del(7)(p11.2p13), - 8, - 9, add( 9)(q34), -10, add(10)(q24), -11,-11,ins(12;?) (q13;?), -14, -14, - 15,ins(1 5;?)(q22;?),add(16)(q22),add(17)(q11.2),-18, der(18)t(7;18)(q11.2;p11.2), - 19, add(20)(p13),add(21)(p11.2),-22,add(22)(p11.2), +6mar in metaphase cell s from primary short-term culture. (C) Elsevier Science Inc., 1999. All rig hts reserved.