A. Dellas et al., Prognostic value of genomic alterations in invasive cervical squamous cellcarcinoma of clinical stage IB detected by comparative genomic hybridization, CANCER RES, 59(14), 1999, pp. 3475-3479
The clinical behavior of invasive cervical carcinoma of clinical stage In v
aries considerably in tumors presenting without regional lymph node metasta
ses, The early identification of patients at higher risk for poor outcome m
ay prove useful because these patients would benefit from aggressive adjuva
nt treatments. In this study, comparative genomic hybridization was applied
to evaluate whether genomic aberrations have prognostic significance in ce
rvical carcinoma. Genomic alterations were evaluated in 62 cervical carcino
mas of clinical stage IB, DNA sequence Losses were most prevalent at chromo
somes 4q (53%), 3p (52%), 13q (45%), 4p (44%), Xq (44%), 5q (40%), 18q (37%
), and 6q (35%), Several genomic alterations were associated with poor clin
ical outcome or metastasis, The total number of DNA aberrations/tumor (P <
0.02) and the number of DNA sequence losses/tumor (P < 0.04) were associate
d with disease-specific survival. 9p deletions were significantly more freq
uent in carcinomas with lymph node metastasis than in node-negative tumors
(P < 0.03), Losses of chromosome lip (P < 0.0001) and 18q (P < 0.01) were a
ssociated with poor prognosis in cervical carcinomas without Lymph node met
astasis, These data suggest that inactivation of tumor suppressor genes on
chromosomes 9p, 11p, and 18q may play a role in the progression of cervical
carcinoma.