Prognostic value of genomic alterations in invasive cervical squamous cellcarcinoma of clinical stage IB detected by comparative genomic hybridization

Citation
A. Dellas et al., Prognostic value of genomic alterations in invasive cervical squamous cellcarcinoma of clinical stage IB detected by comparative genomic hybridization, CANCER RES, 59(14), 1999, pp. 3475-3479
Citations number
32
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER RESEARCH
ISSN journal
00085472 → ACNP
Volume
59
Issue
14
Year of publication
1999
Pages
3475 - 3479
Database
ISI
SICI code
0008-5472(19990715)59:14<3475:PVOGAI>2.0.ZU;2-A
Abstract
The clinical behavior of invasive cervical carcinoma of clinical stage In v aries considerably in tumors presenting without regional lymph node metasta ses, The early identification of patients at higher risk for poor outcome m ay prove useful because these patients would benefit from aggressive adjuva nt treatments. In this study, comparative genomic hybridization was applied to evaluate whether genomic aberrations have prognostic significance in ce rvical carcinoma. Genomic alterations were evaluated in 62 cervical carcino mas of clinical stage IB, DNA sequence Losses were most prevalent at chromo somes 4q (53%), 3p (52%), 13q (45%), 4p (44%), Xq (44%), 5q (40%), 18q (37% ), and 6q (35%), Several genomic alterations were associated with poor clin ical outcome or metastasis, The total number of DNA aberrations/tumor (P < 0.02) and the number of DNA sequence losses/tumor (P < 0.04) were associate d with disease-specific survival. 9p deletions were significantly more freq uent in carcinomas with lymph node metastasis than in node-negative tumors (P < 0.03), Losses of chromosome lip (P < 0.0001) and 18q (P < 0.01) were a ssociated with poor prognosis in cervical carcinomas without Lymph node met astasis, These data suggest that inactivation of tumor suppressor genes on chromosomes 9p, 11p, and 18q may play a role in the progression of cervical carcinoma.