Antiallergic agent from natural sources. 2. Structures and leukotriene release-inhibitory effect of torososide B and torosachrysone 8-O-6 ''-malonyl beta-gentiobioside from Cassia torosa CAV.

Two new anti-allergic compounds, torososide B and torosachrysone 8-O-6 "-ma lonyl gentiobioside were isolated from the seeds of Cassia torosa CAV., and their structures were established as physcion 8-O-beta-D-glucopyranosyl-(1 -->6)-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranosyl-( 1-->6)-beta-D-g lucopyranoside and torosachrysone 8-O-beta-D-glucopyranosyl-(1-->6)-6-malon yl po-glucopyranoside on the basis of spectral and chemical evidence. Torososide B and torosachrysone 8-O-6 "-malonyl gentiobioside were found to inhibit the release of leucotrienes from rat peritoneal mast cells induced by calcium ionophore A 23187.