New dipeptides containing thiazolidine-4-carboxylic acid derivatives: Synthesis and characterization using NMR techniques and X-ray data

Authors
Pellegrini, N Refouvelet, B Crini, G Blacque, O Kubicki, MM Robert, JF
Citation
N. Pellegrini et al., New dipeptides containing thiazolidine-4-carboxylic acid derivatives: Synthesis and characterization using NMR techniques and X-ray data, CHEM PHARM, 47(7), 1999, pp. 950-955
Citations number
34
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
7
Year of publication
1999
Pages
950 - 955
Database
ISI
SICI code
0009-2363(199907)47:7<950:NDCTAD>2.0.ZU;2-X
Abstract
New dipeptides, structural analogues of known immunomodulating agents, were prepared by stereospecific condensation between 2-substituted thiazolidine -4-carborylate esters with N-substituted L-proline or L-thiaproline, The st ructure of these compounds has been elucidated by combination of NMR method s and X-ray analysis. In addition, NMR measurements on dipeptides indicated the presence of S-cis and S-trans conformers around the amide bonds.