Studies on constituents with cytotoxic activity from the stem bark of Syringa velutina

Citation
Hj. Park et al., Studies on constituents with cytotoxic activity from the stem bark of Syringa velutina, CHEM PHARM, 47(7), 1999, pp. 1029-1031
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
7
Year of publication
1999
Pages
1029 - 1031
Database
ISI
SICI code
0009-2363(199907)47:7<1029:SOCWCA>2.0.ZU;2-T
Abstract
Cytotoxic compounds, oleuropein (1) and a phenylethanoid glycoside (2) were isolated from the stem bark of Syringa velutina KOM. along with coniferyla ldehyde 4-O-glucoside, syringin, ligstroside, (+)-syringaresinol 4-O-glucos ide, (+)-medioresinol 4"-O-glucoside and (-)-olivil 4"-O-glucoside. Phenyle thanoid glycoside (2) was identified to be 3,4-dihydroxyphenylethyl alcohol 8-O-beta-D-glucopyranoside. This compound showed the most potent cytotoxic effect on several tumor cell lines (P-388, L-1210, SNU-5 and HL-60) among eight compounds isolated in the present study. We suggest that the 3,4-dihy droxyphenylethoxy moiety of this compound contributes to cytotoxicity.