Wegener's granulomatosis and alpha(1)-antitrypsin-deficiency emphysema - Proteinase-related diseases

Authors
Barnett, VT Sekosan, M Khurshid, A
Citation
Vt. Barnett et al., Wegener's granulomatosis and alpha(1)-antitrypsin-deficiency emphysema - Proteinase-related diseases, CHEST, 116(1), 1999, pp. 253-255
Citations number
7
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
CHEST
ISSN journal
00123692 → ACNP
Volume
116
Issue
1
Year of publication
1999
Pages
253 - 255
Database
ISI
SICI code
0012-3692(199907)116:1<253:WGAAE->2.0.ZU;2-V
Abstract
Wegener's granulomatosis (WG) and alpha(1)-antitrypsin (alpha(1)-AT)-defici ency emphysema are both uncommon disorders. A relationship may exist betwee n these diseases involving the proteinase and antiproteinase balance in the lung. A case is presented of WC and alpha(1)-AT-deficiency emphysema occur ring in the same patient. Previous studies concerning the correlation betwe en abnormal alpha(1)-AT alleles and WG are discussed. Potential mechanisms for the relationship and recommendations for screening are given.