Bisalbuminuria in an adult with bisalbuminemia and nephrotic syndrome

Bisalbuminemia (or alloalbuminemia) is a relatively rare hereditary or acqu ired condition characterized by the presence of two distinct albumin bands, or, less commonly, a single widened albumin band, after agarose gel electr ophoresis of serum. Bisalbumins are caused by point- or chain-mutations tha t occur with a population frequency of 1:10 000 to 1:1000. Although no adve rse clinical effects have been attributed to bisalbumins, some albumin vari ants have altered affinity for steroid hormones, thyroxine, or drugs. We re port a case of bisalbuminuria in a 25-year-old man with bisalbuminemia and nephrotic syndrome. (C) 1999 Elsevier Science B.V. All rights reserved.