Bile salt activation of stress response promoters in Escherichia coli

Citation
C. Bernstein et al., Bile salt activation of stress response promoters in Escherichia coli, CURR MICROB, 39(2), 1999, pp. 68-72
Citations number
40
Categorie Soggetti
Microbiology
Journal title
CURRENT MICROBIOLOGY
ISSN journal
03438651 → ACNP
Volume
39
Issue
2
Year of publication
1999
Pages
68 - 72
Database
ISI
SICI code
0343-8651(199908)39:2<68:BSAOSR>2.0.ZU;2-E
Abstract
Bile salts are prevalent in the mammalian intestine, a natural habitat of E scherichia coli. The bile salts deoxycholate, chenodeoxycholate, ursodeoxyc holate, and glycocholate were tested for their effect on induction of 13 sp ecific stress response genes. The most consistently activated E. call promo ters were those for genes micF, osmY, and dinD. MicF and osmY gene products are associated with membrane functions and are responsive to oxidative str ess. DinD is induced by DNA damage as part of the SOS response. These resul ts indicate that bile acids, to which E. call are naturally exposed, induce expression of specific stress response genes, possibly in response to memb rane perturbation, oxidative stress, and DNA damage. Altered expression of stress-response genes may also promote interaction of E. coli with cells of the colonic epithelium.