Each year in the United States, more than 2 million patients are hospitaliz
ed with chest pain suggestive of myocardial ischemia, with fewer than 20% o
f these patients having an acute coronary event. Chest pain emergency units
have been created to facilitate urgent therapy for patients with a serious
cardiovascular event and to triage lower risk patients to less intensive,
more cost-effective inpatient care or discharge to home, The clinical histo
ry, physical examination, and initial electrocardiogram are key to initial
stratification of patients for further management, but additional methods a
re necessary to clearly distinguish patients with inconclusive findings at
presentation as high- and low-risk. Innovative electrocardiographic methods
have increased sensitivity for detecting myocardial ischemia, Accelerated
diagnostic protocols with new cardiac serum markers can detect myocardial i
schemia or infarction with increasing accuracy, Early echocardiographic, sc
intigraphic, and treadmill stress protocols can further evaluate patients w
ho have nondiagnostic electrocardiograms and negative serum markers. This r
eview presents the current status of chest pain emergency units and the evo
lving management strategies they encompass. Curr Opin Cardiol 1999, 14:321-
328 (C) 1999 Lippincott Williams & Wilkins, Inc.