Type 2 diabetes mellitus: Association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism

We studied by PGR-RFLP 6 polymorphisms in these 5 candidate genes: Ala54Thr in the fatty acid binding protein 2 gene (FABP2), A to G substitution in t he uncoupling protein type 1 gene (UCP1), Asp905Tyr in the protein phosphat ase type 1 gene (PP1G), Trp64Arg in the human beta 3 adrenergic receptor ge ne (beta 3AR) and 2 RFLP sites of the vita; min D receptor (VDR) gene (VDRT aq1 and VDRApa1). This study was conducted among 89 cases and 100 controls matched according to age, gender and absence of first degree family link (1 1 triplets with 2 controls for 1 case and 78 pairs with 1 control for 1 cas e). Gases and controls were taken among a sample of 429 individuals selecte d for the study of the prevalence of diabetes in this ethnic group from Gua deloupe. By conditional logistic regression analysis, there was a significa nt relation (p=0.02) between the Ala54Thr FABP2 polymorphism and Type 2 DM. Multivariate analysis discriminate the FABP2 polymorphism (p=0.10), a trig lyceridemia over 2 g/l (p< 10(-3)) and high blood pressure (p=10(-2)) as va riables associated with Type 2 DM in this population. These findings sugges t that FABP2 does not represent a major gene for Type 2 DM in this migrant Indian population living in Guadeloupe, hut seems to be related to the meta bolic insulin resistance syndrome.