Endothelin release by capsaicin in isolated working rat heart

Capsaicin (1 nM-1 mu M) induced a concentration-dependent decrease in heart rate, coronary flow, aortic flow, left ventricular developed pressure and its first derivative, dP/dt(max) in isolated working rat heart. The effect of 10 nM capsaicin was mimicked by 0.1 nM endothelin. PD142893 (200 nM), a non-selective endothelin receptor blocking agent antagonized the effect of either endothelin (0.1 nM) or capsaicin (10 nM). We conclude that the major ity of the effects of capsaicin in the rat heart are mediated by neural end othelin release. (C) 1999 Elsevier Science B.V. All rights reserved.