Protection by 2-deoxy-D-glucose against beta,beta '-iminodipropionitrile-induced neurobehavioral toxicity in mice

This investigation was undertaken to study the effect of a-deoxy-D-glucose (2-DG) on beta,beta'-iminodipropionitrile (IDPN)-induced neurobehavioral to xicity in mice. Animals were divided into five groups of nine animals each. One of the groups served as control and received vehicle only, whereas the remaining four groups were treated with IDPN (250 mg/kg, ip) daily for 11 days, 2-DG was injected intraperitoneally in the doses of 0 (vehicle only), 100, 300, and 600 mg/kg daily 30 min before IDPN administration. The anima ls were observed for dyskinetic behavior including vertical (retrocollis) a nd horizontal (laterocollis) head movements and circling. Twenty-four hours after the last dose of IDPN, the animals were sacrificed by decapitation a nd striata were isolated from the brain for the analysis of serotonin (5-HT ). Our results showed that 2-DG significantly and dose dependently attenuat ed the incidence and severity of IDPN-induced neurobehavioral toxicity. Adm inistration of 2-DC: also protected mice against IDPN-induced increase in s triatal 5-HT levels. Further studies are warranted to investigate the neuro protective mechanism of 2-DG; against IDPN-induced neurotoxicity. (C) 1999 Academic Press.