Adenine nucleotides as modulators of ornithine decarboxylase from mouse liver and Ehrlich carcinoma cells

It was determined that AMP, ADP, ATP are modulators of the ornithine decarb oxylase (ODC) from mouse liver and Ehrlich carcinoma cells. ATP proved to b e an allosteric inhibitor of ODC. Inhibition constant for ODC from Ehrlich carcinoma cells and liver are 1.06 and 8.2 mM correspondingly. ADP also inh ibits ODC activity, but worse than ATP; and AMP activates decarboxylation p rocess. Activation constants are 17 and 7.8 mM for Ehrlich carcinoma cells and liver correspondingly. It has been concluded that adenine nucleotides p lay the role of metabolism-integrating modulators in Ehrlich carcinoma cell s as well as that biosynthesis of polyamines is under control of cell energ etics.