Qf. Ma et al., NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia, GENE DEV, 13(13), 1999, pp. 1717-1728
Different classes of sensory neurons in dorsal root ganglia (DRG) are gener
ated in two waves: large-diameter trkC(+) and trkB(+) neurons are born firs
t, followed by small-diameter trkA(+) neurons. All such neurons require eit
her neurogenin (ngn) 1 or 2, two neuronal determination genes encoding basi
c helix-loop-helix (bHLH) transcription factors, ngn2 is required primarily
if not exclusively for the generation of trkC+ and trkB+ neurons, whereas
the generation of most or all trkA(+) neurons requires ngn1. Comparison wit
h previous lineage tracing data in the chick suggests that this dichotomy r
eflects a requirement for the two ngns in distinct sensory precursor popula
tions. The neurogenesis defect in ngn2(-/-) embryos is transient and later
compensated by ngn1-dependent precursors, suggesting that feedback or compe
titive interactions between these precursors may control the proportion of
different neuronal subtypes they normally produce. These data reveal remark
able parallels in the roles of bHLH factors during neurogenesis in the DRG,
and myogenesis in the neighboring myotome.