Endometrial carcinoma associated with pregnancy: A report of three cases and review of the literature

Endometrial carcinoma associated with pregnancy is uncommon. In case 1, a 4 0-year-old gravida 2, para 2, was diagnosed with focal well-differentiated papillary adenocarcinoma 4 months postpartum. In case 2, a 35-year-old grav ida 1, para 0, was diagnosed with a well-differentiated papillary adenocarc inoma of the endometrium after a D&C for an incomplete abortion at 7 weeks gestation. In case 3, a 32-year-old gravida 2, para 1, was diagnosed with a moderately differentiated adenocarcinoma with squamous metaplasia 4 months postpartum. All are without evidence of disease more than 2 years after th erapy. A literature review shows 24 previous cases of pregnancy associated with endometrial cancer. These cases demonstrate the importance of endometr ial sampling for abnormal postpartum bleeding despite the protective effect s of pregnancy. (C) 1999 Academic Press.