Evidence for linkage between essential hypertension and a putative locus on human chromosome 17

Authors
Baima, J Nicolaou, M Schwartz, F DeStefano, AL Manolis, A Gavras, I Laffer, C Elijovich, F Farrer, L Baldwin, CT Gavras, H
Citation
J. Baima et al., Evidence for linkage between essential hypertension and a putative locus on human chromosome 17, HYPERTENSIO, 34(1), 1999, pp. 4-7
Citations number
24
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
HYPERTENSION
ISSN journal
0194911X → ACNP
Volume
34
Issue
1
Year of publication
1999
Pages
4 - 7
Database
ISI
SICI code
0194-911X(199907)34:1<4:EFLBEH>2.0.ZU;2-T
Abstract
Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environ mental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 huma n study of French and UK sib pairs, evidence for linkage has been reported to human chromosome 17q, the syntenic region of the rat chromosome 10 quant itative trait loci (QTL). Our study confirms this linkage (P=0.0005) and re fines the location of the blood pressure QTL.