Synthesis and Na+/H+ exchange inhibitory activity of indanylideneacetylguanidines

Authors
Ramakrishna, NVS Jain, AK Ghate, AV Gupte, RD Vadlamudi, RVSV
Citation
Nvs. Ramakrishna et al., Synthesis and Na+/H+ exchange inhibitory activity of indanylideneacetylguanidines, I J CHEM B, 38(4), 1999, pp. 407-412
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
4
Year of publication
1999
Pages
407 - 412
Database
ISI
SICI code
0376-4699(199904)38:4<407:SANEIA>2.0.ZU;2-V
Abstract
Synthesis of indanylideneacetylguadines 7a-i and their corresponding reduce d compounds 8a-e has been achieved and their Na+/H+ exchange inhibitory act ivity evaluated. All the compounds studied exhibit significant inhibition o f Na+/H+ exchanger activity. Promising activity is shown by compounds 7g, H b and 8d. From the structure activity analysis, it appears that reduction o f exocyclic double bond is associated with a marked increase in inhibitory activity.