Synthesis of azetidinones and thiazolidinones from hydrazinopyrimidine as potential antimicrobial agents

6-p-Anisyl-5-cyano-2-hydrazino-3-N-methyl-3,4-dihydropyrimidin-4-one 3 on t reatment with different aromatic aldehydes yields schiffs bases 4a-q which on reaction with chloroacetyl chloride and Et3N in dioxane furnishes respec tive 2-azetidinones 5a-g. Compounds 4a-q on cyclisation with thioglycolic a cid afford corresponding 4-thiazolidinones 6a-I. All the products have been evaluated for their in vitro growth inhibitory activity against several mi crobes like B, megaterium, B. subtilis, E. coli, Ps. fluorescens and A. awa mori. The structures of the products 4a-q, 5a-g and 6a-i have been elucidat ed by elemental analyses and spectral data.