Fused heterocycles: Synthesis and fungistatic activity of some 1-aroyl/aryloxyaceto-4-aryl-5-cyano-3-methyl 1,4,5,6,7-pentahydropyrazolo[4,5-e]pyridin-6-ones and 1-aroyl/aryloxyaceto-4-aryl-3-methyl-1,4-dihydropyrazolo[4,5-e]pyrido[1,2-a]pyrimidines

Authors
Khan, MH Haque, R Agrawal, T Safi, A",Nizamuddin
Citation
Mh. Khan et al., Fused heterocycles: Synthesis and fungistatic activity of some 1-aroyl/aryloxyaceto-4-aryl-5-cyano-3-methyl 1,4,5,6,7-pentahydropyrazolo[4,5-e]pyridin-6-ones and 1-aroyl/aryloxyaceto-4-aryl-3-methyl-1,4-dihydropyrazolo[4,5-e]pyrido[1,2-a]pyrimidines, I J CHEM B, 38(4), 1999, pp. 452-456
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
4
Year of publication
1999
Pages
452 - 456
Database
ISI
SICI code
0376-4699(199904)38:4<452:FHSAFA>2.0.ZU;2-N
Abstract
A number of 1-aroy/aryloxyaceto-4-aryl-5-cyano-3-methyl 1,4,6,7-pentahydrop yrazolo[4,5-e] pyridin-6-ones 3 and 1,aroyl/aryloxyaceto-4-aryr-3-methyl-1, 4-dihydropyrazolo[4,5-e]pyrido[1,2-a]pyrimidines 4 have been prepared by Mi chael addition between alpha,beta-unsaturated ketones 2 and ethyl cyanoacet ate/2-aminopyridine in the presence of ammonium acetate. These compounds ha ve been evaluated for their fungistatic activity against P. oryzae, R. sola ni, P cubensis and P infestans.