Infectivity of Plasmodium berghei sporozoites delivered by intravenous inoculation versus mosquito bite: Implications for sporozoite vaccine trials

Authors
Vaughan, JA Scheller, LF Wirtz, RA Azad, AF
Citation
Ja. Vaughan et al., Infectivity of Plasmodium berghei sporozoites delivered by intravenous inoculation versus mosquito bite: Implications for sporozoite vaccine trials, INFEC IMMUN, 67(8), 1999, pp. 4285-4289
Citations number
56
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
8
Year of publication
1999
Pages
4285 - 4289
Database
ISI
SICI code
0019-9567(199908)67:8<4285:IOPBSD>2.0.ZU;2-5
Abstract
Plasmodium berghei sporozoites delivered by mosquito bite were more infecti ous to outbred CD-1 mice than were sporozoites delivered by intravenous ino culation. The route of challenge also affected vaccine efficacy. In view of these findings and the fact that mosquito bites are the natural mode of sp orozoite delivery, infectious mosquito bites should be considered the chall enge protocol of choice for sporozoite vaccine efficacy trials.