Nefazodone-induced clitoral priapism

A case is presented of painful priapism of the clitoris lasting 3 days, wit h a strong temporal association with the administration of nefazodone hydro chloride. Priapism has been described as a rare side-effect of drugs with h igh alpha(1)-adrenergic blocking potential. However, the alpha(1)-adrenergi c blocking potential of nefazodone is moderate. Drug induced clitoral priap ism has been described for citalopram, bromocriptine, fluoxetine and trazod one combined with fluoxetine. To our knowledge, this is the first report in the literature about priapism of the clitoris associated with nefazodone. Int Clin Psychopharmacol 14:257-258 (C) 1999 Lippincott Williams & Wilkins.