Purpose: Preliminary assessment of feasibility, efficacy, acute and chronic
side effects associated with permanent intraoperative placement of I-125 v
icryl mesh brachytherapy in a select group of high-risk Stage I NSCLC who h
ave undergone video-assisted thoracoscopic resection (VATR).
Methods and Materials: From January 8, 1997 to March 16, 1998, 23 patients
with Stage I NSCLC at high risk for conventional surgery due to cardiopulmo
nary compromise underwent combined VATR and intraoperative placement of I-1
25 seeds embedded in vicryl mesh. Seeds embedded in vicryl suture were atta
ched with surgical clips to a sheet of vicryl mesh, and thoracoscopically i
nserted over the target area (tumor bed and staple line) with nonabsorbable
suture or surgical clips. A total dose of 100-120 Gy prescribed to the per
iphery of the target area (defined as the staple line and tumor bed with a
l-cm margin) was delivered.
Results: The mean target area covered was 48 cm(2) (range 40-72) and mean t
otal activity was 22 mCi (range 17.2-28.2). The median length of postoperat
ive stay was 7 days. The median follow-up was 11 months (range 2-20). Posto
perative CT scans of the chest revealed no dislodgement of the seeds and no
local recurrence in any patient. Three patients developed distant metastas
is (1 died 6 months postoperatively; the other 2 are currently alive with d
isease). One patient developed an ipsilateral recurrence in the right lower
lobe after having had a right upper lobe resection, There were 3 postopera
tive deaths due to medical comorbid conditions or surgical complications (1
in the immediate postoperative period). Pulmonary function testing perform
ed 3 months after implantation revealed no significant difference between p
reoperative and postoperative values: mean preoperative FVC was 2.3 L (rang
e 1.31-3.0) and postoperative FVC was 2.2 L (range 1.1-3.9), p = 0.42; mean
preoperative FEV, was 1.2 L (range 0.71-2.2), and postoperative FEV, was 1
.5 L (range 0.8-2.9), p = 0.28.
Conclusion: Review of early data suggests that intraoperative I-125 vicryl
mesh brachytherapy in high-risk Stage INSCLC is potentially effective and w
ell tolerated, with no significant decline in measurable pulmonary function
studies and no increase in postoperative complications. Longer follow-up i
s needed to determine ultimate local control and survival. (C) 1999 Elsevie
r Science Inc.