R. Roeder et al., Compliance, elastic modulus, and burst pressure of small-intestine submucosa (SIS), small-diameter vascular grafts, J BIOMED MR, 47(1), 1999, pp. 65-70
Small-intestine submucosa (SIS) is cell-free collagen, 100 mu Chick, derive
d from the small intestine. It has been used as a vascular graft and has th
e highly desirable property of remodeling itself to become host tissue. To
date there has been limited reportage on its preimplantation mechanical pro
perties as a vascular graft. In this study, compliance, elastic modulus, an
d burst pressure have been measured on 5- and 8-mm SIS grafts. The complian
ce (percent of diameter increase for a pressure rise from 80 to 120 mmHg) w
as 4.6% av (range 2.9 to 8.6%) for the 5-mm grafts. For the 8-mm graft, the
increase in diameter for the same pressure rise was 8.7% av (range 7.2 to
9.5%). The modulus of elasticity (E) increased exponentially with increasin
g pressure according to E = E(o)e(alpha P); where E-o is the zero-pressure
modulus and alpha is the exponent that describes the rate of increase in E
with pressure; the units for E, E-o, and P are g/cm(2). The mean value for
E-o was 4106 (g/cm(2) range 1348-5601). The mean value for alpha was 0.0059
(range 0.0028-0.0125). At 100 mmHg, the mean value for E was 8.91 x 10(3)
g/cm(2) (range 1.02-8.80 x 10(3)). The mean burst pressure for 5.5-mm graft
s was 3517 mm Hg (range 2069-4654). in terms of preimplant compliance, the
small-diameter SIS graft is about 1/2 as compliant as the dog carotid arter
y, about four times more compliant than a typical vein graft, and more than
an order of magnitude more compliant than synthetic vascular grafts. (C) 1
999 John Wiley & Sons, Inc.