Typing of clinical herpes simplex virus type 1 and type 2 isolates with monoclonal antibodies

Authors
Liljeqvist, JA Svennerholm, B Bergstrom, T
Citation
Ja. Liljeqvist et al., Typing of clinical herpes simplex virus type 1 and type 2 isolates with monoclonal antibodies, J CLIN MICR, 37(8), 1999, pp. 2717-2718
Citations number
17
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
00951137 → ACNP
Volume
37
Issue
8
Year of publication
1999
Pages
2717 - 2718
Database
ISI
SICI code
0095-1137(199908)37:8<2717:TOCHSV>2.0.ZU;2-Z
Abstract
The purpose of this study was to evaluate the performance of a herpes simpl ex virus (HSV) type 1-specific anti-glycoprotein C-1 monoclonal antibody (M Ab) and a type 2-spetific anti-glycoprotein G-2 MAb for typing of 2,400 cli nical HSV-1 isolates and 2,400 clinical HSV-2 isolates, respectively, using an enzyme immunoassay. The anti-HSV-1 MAb showed sensitivity and specifici ty of 100%, and the anti-HSV-2 MAb showed a sensitivity of 99.46% and 100% specificity, indicating that these MAbs are suitable for typing of clinical HSV isolates.