Low literacy may be an important predictor of increased cancer risk and poo
r participation in cancer control programs. Results of the National Adult L
iteracy Survey indicate that about 90 million individuals, slightly less th
an half of the U.S. adult population, demonstrate low or limited literacy s
kills. In contrast, the average health education brochure, pamphlet, or ins
truction sheet requires a 10th-grade or higher level of reading ability to
be understood. Guidelines exist for the development of move readable printe
d materials; studies have also found that nonprint approaches such as video
education are viable alternatives to printed materials. Research on patien
t populations indicates that educational approaches targeted to low-literac
y groups can be effective in reaching individuals with cancer control infor
mation. This review identifies the most important areas of needed research
and makes recommendations for the development of a research agenda on cance
r control and literacy.