Harmonic grey scale imaging of the human brain

Harmonic imaging increases the signal-to-noise ratio in grey-scale imaging. With the use of ultrasound contrast agents (UCA), imaging of brain perfusi on seems possible. The authors used an ultrasound system in connection with a 1.8/3.6-MHz harmonic sector transducer and an acoustic densitometry unit for quantification of ultrasound intensity in the thalamus (THAL), the tem poroparietal white matter (TPWM), and the lateral fissure (LF). Ten millili ters of BY963, a spherosome-air-based UCA, was injected intravenously in 12 healthy volunteers. Time-intensity curves were calculated. Mean increase o f intensity (standard deviation [SD]), mean area under the time-intensity c urve (AUC) from baseline (SD), and mean transit time (MTT) (SD) in the regi on of LF, THAL, and TPWM were 2.2 +/- 1.7, 1.1 +/- 0.6, 0.9 +/- 0.9 dB and 16.7 +/- 22.7, 4.7 +/- 4.7, 3.7 +/- 6.3 as well as 11.1 +/- 3.5, 9.7 +/- 3. 1, and 11.9 +/- 8.0, respectively. There was a statistically significant di fference for mean AUC (p = 0.02) but none comparing mean intensity increase (p = 0.07) and MTT (p = 0.9). The authors' study indicates that different regions of the human brain show different time-intensity curves. These resu lts suggest that it is possible to measure parameters closely related to pe rfusion in various regions of the adult human brain.