A screen of candidates from peaks of linkage: evidence for the involvementof myeloperoxidase in multiple sclerosis

We tested 11 microsatellite markers for evidence of transmission distortion in 744 trio families with multiple sclerosis. Ten of the markers lie withi n or near to candidate genes selected on the basis that they map within the regions of potential linkage identified in our previously reported linkage genome screen, while the eleventh is an anonymous marker which had previou sly shown modest evidence for transmission distortion in our sibling pair f amilies. Only the marker related to the myeloperoxidase (MPO) gene revealed tentative evidence for linkage disequilibrium and further work on this gen e is clearly needed in order to resolve the status of this region in confer ring susceptibility to multiple sclerosis. (C) 1999 Elsevier Science B.V. A ll rights reserved.