Synthesis of enantiopure alpha '-amino alpha,beta-epoxy ketones from alpha'-amino bromomethyl ketones

Preparation of enantiomerically pure alpha'-amino alpha,beta-epoxy ketones 2 in an efficient synthesis starting from alpha'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 ar e described. We also report the generalization of the synthesis of 1-aminoa lkyl halomethyl ketones to their bromo derivatives.