Left ventricular hypertrophy: Population and molecular genetic study

Relationship between ECC signs of left ventricular hypertrophy and angioten sin-converting enzyme gene polymorphism was assessed in a population and fa mily based case-control study in Novosibirsk. Prevalence of myocardial hype rtrophy in men aged 35-54 years was 22,9% with obvious aggregation of cases in families. Frequencies of alleles of angiotensin-converting enzyme gene (I-45%, D-55%) were similar to those observed in European countries. No ass ociations were found between ACE gene polymorphism and blood pressure level , frequencies of hypertension, increased myocardial mass, and left ventricu lar hypertrophy.