PARALLEL COMPUTATION ENABLES PRECISE DESCRIPTION OF CA2-TERMINALS( DISTRIBUTION IN NERVE)

Authors
AHARON S BERCOVIER M PARNAS H
Citation
S. Aharon et al., PARALLEL COMPUTATION ENABLES PRECISE DESCRIPTION OF CA2-TERMINALS( DISTRIBUTION IN NERVE), Bulletin of mathematical biology, 58(6), 1996, pp. 1075-1097
Citations number
35
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Biology Miscellaneous","Mathematics, Miscellaneous
Journal title
Bulletin of mathematical biology → ACNP
ISSN journal
00928240
Volume
58
Issue
6
Year of publication
1996
Pages
1075 - 1097
Database
ISI
SICI code
0092-8240(1996)58:6<1075:PCEPDO>2.0.ZU;2-U
Abstract
Parallel computation employing a domain decomposition method was used to calculate precisely without approximations the spatio-temporal dist ribution of Ca2+ in nerve terminals. The results showed, contrary to e xpectations, that for equal admitted Ca2+ currents at low (one channel open) and high (four channels open) depolarization, the average Ca2concentration at the release area is higher at the low depolarization. These calculations provide additional support for the Ca2+-voltage hy pothesis for neurotransmitter release. (C) 1996 Society for Mathematic al Biology