The use of central muscle relaxant tizanidine in the cardialgia syndrome

Potential of a central muscle relaxant tizanidine to alleviate concomitant cardialgia was studied in 30 patients (11 men and 19 women, mean age 45,2 y ears) with psyche-vegetative or myofascial syndromes after exclusion of car diovascular causes of chest pain. Control group comprised 14 healthy person s. Pain was assessed both subjectively and objectively using visual analog scales, questionnaires and palpation. The state of vegetative nervous syste m and psychic status were evaluated by rating questionnaires and tests of S pilberger (detection of reactive and personality anxiety) and Bek (evaluati on of depression). Studies were done before and after administration of tiz anidine (6-8 mg/day for 20 days). Regression of clinical sings of the cardi algia syndrome and psyche-vegetative disturbances was observed after treatm ent Effect of therapy was considered good, satisfactory and unsatisfactory in 33, 47 and 20% of patients, respectively Thus the use of a central muscl e relaxant tizanidine in patients with psyche-vegetative and myofascial syn dromes and concomitant cardialgia was associated with clinical improvement.