C. Lopes et al., Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1, MECH DEVEL, 84(1-2), 1999, pp. 189-193
Thr gene tprd. which contains three tetratricopeptide domains, has been rec
ently localized in the Down syndrome (DS) chromosomal region 1. We have clo
ned a cDNA encoding part of the murine ortholog of tprd and used it to char
acterize the expression pattern of this gene during development and at the
adult stage. At E8.5 the expression is uniform. In the later stages of embr
yogenesis, although expression remains ubiquitous, a pattern of tissues wit
h particularly high expression develops: the strong expression is restricte
d to non proliferating zones of the nervous system such as the external lay
er of the cortex, the spinal cord, the cranial and root ganglia and the ner
ves. In the brain of adult mouse the strongest signals are observed in laye
rs II-III and V-VI of the cortex, in the hippocampus and in the cerebellum,
which correspond to the abnormal brain regions seen in DS patients. (C) 19
99 Elsevier Science Ireland Ltd. All rights reserved.