The authors studied 14 patients with dementia with Lewy bodies (DLB), 14 pa
tients with AD, and 14 healthy control subjects with N-isopropyl-p-[I-123]i
odoamphetamine SPECT. Comparison with the statistical parametric mappings r
evealed that relative cerebral blood flow was lower in the occipital lobes
and higher in the right medial temporal lobe in the DLB group than in the A
D group. Decreased occipital perfusion and relatively well preserved medial
temporal perfusion are features that distinguish DLB from AD.