Dynamics of Helicobacter pylori colonization in relation to the host response

The dynamics of Helicobacter pylori colonization from its acquisition throu gh the development of steady-state are examined through a mathematical mode l that includes the host response. The model encompasses both host and micr obiological variation. The individual capacity of the host response is show n to be a key model parameter, leading to either transient or persistent co lonization, whereas the growth rate of that response has little effect. Ana lyses of competing strains indicate that each must occupy a specific niche, otherwise exclusion occurs. The model implies that there exists a lower bo und on the host response to the indigenous microflora that is consistent wi th current biological views of H. pylori. Parallel models may be useful in understanding other persistent host-microbial interactions.