Synthesis and reactivity of high-molecular-mass phosphorylated poly(ethylene glycol)

Authors
Pace, G Veronese, FM Bonora, GM
Citation
G. Pace et al., Synthesis and reactivity of high-molecular-mass phosphorylated poly(ethylene glycol), REACT FUNCT, 41(1-3), 1999, pp. 141-148
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
REACTIVE & FUNCTIONAL POLYMERS
ISSN journal
13815148 → ACNP
Volume
41
Issue
1-3
Year of publication
1999
Pages
141 - 148
Database
ISI
SICI code
1381-5148(19990715)41:1-3<141:SAROHP>2.0.ZU;2-0
Abstract
New phosphorylated monomethoxy poly(ethylene glycol)s (MPEGs) were obtained and used to prepare diMPEG-conjugated oligonucleotides. The chemical simil arity with other organic molecules carrying diester bonds can be easily env isaged, allowing for further applications of these new MPEG units. Both hig h-molecular-mass phosphodiester- and phosphoramidite-derivatives have been obtained, characterized and evaluated for their reactivity. (C) 1999 Elsevi er Science B.V. All rights reserved.