Synthesis of peptide aldehydes on solid support

Peptide aldehydes are of great interest as enzyme inhibitors and as startin g materials for further chemistry. The solid phase synthesis of such entiti es is presented through three different approaches: a Weinreb amide linker, a phenyl ester linker, which both can be reduced with hydrides to yield th e target molecules, and finally an unsaturated linker which produces the de sired compounds by ozonolysis. (C) 1999 Elsevier Science B.V. All rights re served.