Glycoproteins: glycan presentation and protein-fold stability

Authors
Wormald, MR Dwek, RA
Citation
Mr. Wormald et Ra. Dwek, Glycoproteins: glycan presentation and protein-fold stability, STRUCT F D, 7(7), 1999, pp. R155-R160
Citations number
35
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE WITH FOLDING & DESIGN
ISSN journal
09692126 → ACNP
Volume
7
Issue
7
Year of publication
1999
Pages
R155 - R160
Database
ISI
SICI code
0969-2126(19990715)7:7<R155:GGPAPS>2.0.ZU;2-R
Abstract
Glycosylation of proteins has been shown to play a role in a variety of cel lular events. Thanks to recent advances in obtaining conformational constra ints across glycosidic linkages, structural characterisation of glycoprotei ns has improved considerably. It is now becoming apparent that N-glycosylat ion of a folded protein can have a significant stabilising effect on large regions of the backbone structure.