K. Mitsukura et al., Synthesis of optically active bisdifluorocyclopropanes through a chemo-enzymatic reaction strategy, TETRAHEDR L, 40(31), 1999, pp. 5739-5742
The first synthesis of bisdifluorocyclopropane derivatives has been accompl
ished via a chemo-enzymatic reaction strategy; (E)- or (Z)-3-tributylstanny
l-2-propenols were prepared and their conversion led to the (trans, trans)-
and(cis, cis) -bisdifluorocyclopropanes. The subsequent lipase-catalyzed r
eaction efficiently afforded optically active (trans, trans)2,2,5,5-tetrafl
uoro-1,6-bis(hydroxymethyl)bicyclopropane. (C) 1999 Published by Elsevier S
cience Ltd. All rights reserved.