1) Pseudo-exfoliation syndrome (PE syndrome) is a condition with worldwide
distribution. 2) Marked geographical variations have been demonstrated. 3)
Environmental factors may be of etiological significance for the developmen
t of PE syndrome. 3) The PE syndrome's ability to promote glaucoma may vary
from one area to another. 5) There seems to be a trend towards lower debut
age of PE syndrome at lower latitudes. 6) More prevalence studies from dif
ferent parts of the world are needed. A standardized set-up of such works w
ould facilitate comparison of the results, and so some guidelines have been
proposed.