Binge drinking and bone metabolism in a young actively growing rat model

Background: Chronic alcohol consumption has been demonstrated to be deleter ious to bone health. However, binge drinking is the prevalent form of drink ing in young people, which was the impetus for the present study to determi ne the effect of week-end and week-long binge drinking on bone health in a young actively growing animal model. Methods: Four-week-old, female, Sprague-Dawley rats were given the amount o f 5% alcohol by gavage to be equivalent to a 63 kg woman drinking six beers a day for either 2 or 5 consecutive days per week. Results: There were no changes in the 5-day binge animals, but the 2-day bi nge animals were hypocalcemic. Similarly, 2-day binge animals had slightly increased bone chemistry and histomorphometric values for both tibia and fe mur, but only femur length dry weight, and ash weight as well as femur dens ity, presented either as g/ml or ash weight per unit volume, were increased by a statistically significant level. Cross-section periosteal Mineral App osition Rate (MAR) was significantly decreased in the 2-day alcohol fed ani mals. Conclusions: Actively growing rats given 5% alcohol by gavage for 2 days pe r week have an increased bone length, bone weight and bone density. The int erpretation of these results must be viewed with great caution because stud ies of chronic alcohol consumption, and many studies of acute drinking, cle arly indicate deleterious effects of alcohol on bone health. Those fed alco hol for 5 days per week showed no change.