Np. Andrews et al., Effect of systemic alpha(-2) adrenergic blockade on the morning increase in platelet aggregation in normal subjects, AM J CARD, 84(3), 1999, pp. 316-320
Citations number
28
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
To assess whether activation of platelets by catecholamines contributes to
the increase in platelet aggregation associated with either the assumption
of upright posture or exercise, we studied the effect of oral yohimbine on
these phenomena. Whole blood platelet aggregation and plasma catecholamine
levels were measured before and after standing and at peak exercise in untr
eated normal subjects and after oral yohimbine. Neurochemical indexes indic
ated systemic alpha(2)-receptor blockade by yohimbine. Yohimbine reduced th
e ortho-static increase in platelet aggregation response by 63 +/- 11%, but
exercise-induced increase in aggregation was unaffected, Thus, alpha(2)-ad
renergic blockade attenuates the orthostatic increase in platelet aggregati
on. Agents designed to inhibit the morning surge in catecholamine levels or
block platelet alpha(2) adrenoceptors may reduce the risk of thrombotic va
scular events in atherosclerosis. (C) 1999 by Excerpta Medico, Inc.