Effect of prolonged administration of transdermal estradiol on flow-mediated endothelium-dependent and endothelium-independent vasodilation in healthy postmenopausal women

Authors
Cagnacci, A Modena, MG Malmusi, S Muia, N Volpe, A
Citation
A. Cagnacci et al., Effect of prolonged administration of transdermal estradiol on flow-mediated endothelium-dependent and endothelium-independent vasodilation in healthy postmenopausal women, AM J CARD, 84(3), 1999, pp. 367
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
84
Issue
3
Year of publication
1999
Database
ISI
SICI code
0002-9149(19990801)84:3<367:EOPAOT>2.0.ZU;2-F
Abstract
In 15 postmenopausal women with no cardiovascular risk factors, hormone rep lacement with transdermal estradiol (50 mu g/day for 2 months) did not enha nce flow-mediated endothelium-dependent vasodilation, reduce endothelium-in dependent vasodilation, and did not modify the pulsatility index and blood flow of the brachial artery. The present data do not support a positive eff ect of replacement with transdermal estradiol on vessel vasodilation in hea lthy, postmenopausal women.