Correlation between LH response to challenges with GNRH and naloxone during lactation, and LH secretion and follicular development after weaning in the sows
F. De Rensis et Gr. Foxcroft, Correlation between LH response to challenges with GNRH and naloxone during lactation, and LH secretion and follicular development after weaning in the sows, ANIM REPROD, 56(2), 1999, pp. 143-152
The aim of this study was of establishing a correlation between endogenous
LH secretion and the magnitude of the LH response to challenges with GnRH a
nd the opioid antagonist naloxone during lactation, and between these chara
cteristics and LH secretion and follicular development after weaning. Sows
(n = 9) were sampled for 6 h at day 2 post-partum, for 12 h on day 26 of la
ctation and for 6 h immediately after weaning at day 27 of lactation. Four
hours after the beginning of sampling at day 26 of lactation all sows were
injected with 2 mg/kg i.v. of naloxone hydrochloride and 5 h later with 100
mu g/sow of GnRH. Follicular development was studied in all sows at slaugh
ter the day after weaning. There was an effect of time (sampling period; P
< 0.001) on mean plasma LH, with an increase (P < 0.05) in LH the day after
weaning compared to mean LH concentrations during lactation. Naloxone and
GnRH treatment both increased (P < 0.05) mean LH concentrations. A positive
relationship (r = 0.58, P < 0.01) between mean plasma LH after GnRH and af
ter weaning was established. Although there were differences (P < 0.001) be
tween sows in follicular fluid volume, there were no correlations between m
ean follicular fluid volume and mean LH concentrations after GnRH or after
weaning. These data indicate that the LH response to GnRH during late lacta
tion could be useful predictor of LH activity after weaning. However, none
of the measures of endogenous or induced LH secretion were associated with
differences in ovarian follicular size after weaning. Direct evidence is th
erefore still needed for afunctional link between differences in LH in lact
ation and differences in fertility after weaning. (C) 1999 Elsevier Science
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