This article describes the modifications occurring in cerebral vessels duri
ng the first 24 h after an ischaemic event followed by reperfusion. The pha
ses of occlusion, no-reflow, post-ischaemic hyperaemia and delayed hypoperf
usion are dealt with in terms of haemodynamic, morphological, functional an
d biochemical data, available especially from animal studies. The interacti
ons of platelets and leucocytes with the endothelium and the major role of
reactive oxygen species in lesioning the microvasculature, including the bl
ood-brain barrier, are emphasized. (C) 1999 Elsevier, Paris.