Pharmacokinetics, metabolism and bioavailability of the new anti-allergic drug BM 113 - Part II: Pharmacokinetics in primates after repeated oral or single intravenous administration

The pharmacokinetics of BM 113 (1-(benzhydryloxyethyl)piperidino-4-ethylace tate, CAS 115313-90-1; BM 113 maleate: CAS 115313-91-2) was studied using H -3-BM 113 in the Cynomolgus primate. Oral repeated administration of 0.75 m g/kg was performed on 8 days. 40 days after the oral treatment, a single in travenous administration of 0.4 mg/kg was done. Whatever the administration route, the radioactivity excretion was essentially urinary (about 60%) and most of the radioactivity was excreted within the first 24 h. The faecal e limination was low, about 10% of the administered dose. 40 days after the t reatment, some radioactivity was already present in the urine. For this. re ason, the excretion balance ranged from 70 to 83% of the dose. The eliminat ion half-life of H-3-BM 113 was long, about 80 h.