Strong diffusional mixing and short delivery times typical for micrometer a
nd sub-micrometer reaction volumes lead to a special situation where the tu
rnover times of individual enzyme molecules become the largest characterist
ic time scale of the chemical kinetics. Under these conditions, populations
of cross-regulating allosteric enzymes form molecular networks that exhibi
t various kinds of self-organized coherent collective dynamics. (C) 1999 El
sevier Science B.V. All rights reserved.