Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells

The adherence of red blood cells (RBC) to endothelial cells (EC), shown to correlate with microvascular occlusion in sickle cell disease and malaria, is considered a major contributor to microcirculatory disorders. In the pre sent study the adherence to EC was markedly enhanced with RBC from beta-tha lassaemia major (TM) patients, and even more so with RBC from beta-thalassa emia intermedia (TI) patients (10-fold and 25-fold higher than normal, resp ectively). It is proposed that enhanced RBC/EC adherence may contribute to the microcirculatory disorders observed in thalassaemia, especially in TI p atients who are particularly known to suffer from leg ulcers.