Organic reaction in water. Part 2: Michael addition in water without phasetransfer agents

Authors
da Silva, FM Gomes, AK Jones, J
Citation
Fm. Da Silva et al., Organic reaction in water. Part 2: Michael addition in water without phasetransfer agents, CAN J CHEM, 77(5-6), 1999, pp. 624-627
Citations number
42
Categorie Soggetti
Chemistry
Journal title
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
ISSN journal
00084042 → ACNP
Volume
77
Issue
5-6
Year of publication
1999
Pages
624 - 627
Database
ISI
SICI code
0008-4042(199905/06)77:5-6<624:ORIWP2>2.0.ZU;2-6
Abstract
The Michael additions of dicarbonyl compounds, nitroalkanes, and thiols to 2-cyclohexen-1-one can be accomplished in water without phase transfer agen ts. The reaction is extremely sensitive to the pH of the reaction media, an d therefore, the methodology can be optimized with the control of this vari able. The best pH depends on the used nucleophile.