Optical resolution of glycerin sulfides and glycerin selenides on the chiral stationary phase of cellulose-tris(3,5-dimethylphenylcarbamate)

Cellulose-tris(3,5-dimethylphenylcarbamate) was prepared after a reported m ethod and was coated onto an aminopropylated mesopore spherical silica gel. The final product was used as a chiral stationary phase of high performanc e liquid chromatography for the enantioseparation of a series of glycerin s ulfides and glycerin selenides. Mixtures of hexane and 2-propanol were used as mobile phases. The effects of 2-propanol concentration in the mobile ph ase on the retention and resolution were investigated. Some enantiomers of the glycerin monosulfides and monoselenides could be separated satisfactori ly, but none of the disulfides could be separated. The structural features of the solutes that influence chiral separation were discussed. (C) 1999 Wi ley Liss, Inc.