K. Ammann et al., Intestinal neuronal dysplasia in adults as a cause of chronic constipation: morphometric characterization of colon innervation, CHIRURG, 70(7), 1999, pp. 771-776
Intestinal neuronal, dysplasia (IND) was initially described as a developme
ntal abnormality of the submucous plexus in children. In recent years this
abnormality has also been observed in adults with chronic constipation. The
aim of this study was a morphometric characterization of this disease. The
investigation was performed with 10 adults with IND, compared with 10 heal
thy control probands. The best diagnostic indicator of IND proved to be the
detection of 6-10 giant ganglia with more than 7 nerve cells in 15 biopsy
sections. IND is an interesting cause of chronic constipation which can be
histologically verified.